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dc.contributor.authorBenevento, Emilia
dc.contributor.authorDjebbari, Abdelghani
dc.contributor.authorCecere, Renzo
dc.contributor.authorKadem, Lyes
dc.contributor.authorKeshavarz Motamed, Zahra
dc.date.accessioned2015-05-29T13:16:36Z
dc.date.available2015-05-29T13:16:36Z
dc.date.issued2015-04
dc.date.submitted2014-05
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/97107
dc.description.abstractAortic valve bypass (AVB) has been shown to be a viable solution for patients with severe aortic stenosis (AS). Under this circumstance, the left ventricle (LV) has a double outlet. The objective was to develop a mathematical model capable of evaluating the hemodynamic performance following the AVB surgery. A mathematical model that captures the interaction between LV, AS, arterial system, and AVB was developed. This model uses a limited number of parameters that all can be non-invasively measured using patient data. The model was validated using in vivo data from the literature. The model was used to determine the effect of different AVB and AS configurations on flow proportion and pressure of the aortic valve and the AVB. Results showed that the AVB leads to a significant reduction in transvalvular pressure gradient. The percentage of flow through the AVB can range from 55.47% to 69.43% following AVB with a severe AS. LV stroke work was also significantly reduced following the AVB surgery and reached a value of around 1.2 J for several AS severities. Findings of this study suggest: 1) the AVB leads to a significant reduction in transvalvular pressure gradients; 2) flow distribution between the AS and the AVB is significantly affected by the conduit valve size; 3) the AVB leads to a significant reduction in LV stroke work; and 4) hemodynamic performance variations can be estimated using the model.en_US
dc.description.sponsorshipFonds quebecois de la recherche sur la nature et les technologies (176048)en_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0123000en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePublic Library of Scienceen_US
dc.titleHemodynamic Changes following Aortic Valve Bypass: A Mathematical Approachen_US
dc.typeArticleen_US
dc.identifier.citationBenevento, Emilia, Abdelghani Djebbari, Zahra Keshavarz-Motamed, Renzo Cecere, and Lyes Kadem. “Hemodynamic Changes Following Aortic Valve Bypass: A Mathematical Approach.” Edited by Alberto Aliseda. PLOS ONE 10, no. 4 (April 16, 2015): e0123000.en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorKeshavarz Motamed, Zahraen_US
dc.relation.journalPLOS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBenevento, Emilia; Djebbari, Abdelghani; Keshavarz-Motamed, Zahra; Cecere, Renzo; Kadem, Lyesen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5853-3887
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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