Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
Author(s)
Cheung, Chi Wai; Buchwald, Stephen Leffler
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A method for the hydroxylation of aryl and heteroaryl halides, promoted by a catalyst based on a biarylphosphine ligand tBuBrettPhos (L5) and its corresponding palladium precatalyst (1), is described. The reactions allow the cross-coupling of both potassium and cesium hydroxides with (hetero)aryl halides to afford a variety of phenols and hydroxylated heteroarenes in high to excellent yield.
Date issued
2014-04Department
Massachusetts Institute of Technology. Department of ChemistryJournal
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Cheung, Chi Wai, and Stephen L. Buchwald. “Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst.” The Journal of Organic Chemistry 79, no. 11 (June 6, 2014): 5351–5358. © 2014 American Chemical Society
Version: Final published version
ISSN
0022-3263
1520-6904