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dc.contributor.advisorThomas Roemer and Brian Anthony.en_US
dc.contributor.authorSazdanoff, Nicholasen_US
dc.contributor.otherLeaders for Global Operations Program.en_US
dc.date.accessioned2015-09-29T18:59:33Z
dc.date.available2015-09-29T18:59:33Z
dc.date.copyright2015en_US
dc.date.issued2015en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/99037
dc.descriptionThesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2015. In conjunction with the Leaders for Global Operations Program at MIT.en_US
dc.descriptionThesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015. In conjunction with the Leaders for Global Operations Program at MIT.en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (pages 64-65).en_US
dc.description.abstractThis thesis evaluates the use of postponement in the Drug Product (DP) supply chain at Amgen, which is characterized by highly variable production lead times. The motivation for the use of postponement in the DP supply chain is to reduce the lead time and improve the service level from the manufacturing site to the distribution centers (DCs). Amgen is undergoing a rapid global expansion and is now serving markets that operate on tender (bid) systems that require rapid fulfillment. To compound this challenge, FDA driven requirements have significantly increased the likelihood of generating Non-Conformances (NCs) in DP manufacturing, which in turn increases the production lead time variability. A simulation model was created in Microsoft Excel that uses historic production lead time and demand data to determine postponement levels and simulate performance of the system. Leveraging the simulation model, this thesis demonstrates that utilizing postponement in supply chains with highly variable production lead times can significantly improve service level and diminish customer lead time while potentially reducing global inventory levels.en_US
dc.description.statementofresponsibilityby Nicholas Sazdanoff.en_US
dc.format.extent65 pagesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectSloan School of Management.en_US
dc.subjectMechanical Engineering.en_US
dc.subjectLeaders for Global Operations Program.en_US
dc.titleEvaluation of postponement in the Drug Product supply chainen_US
dc.title.alternativeEvaluation of postponement in the DP supply chainen_US
dc.typeThesisen_US
dc.description.degreeM.B.A.en_US
dc.description.degreeS.M.en_US
dc.contributor.departmentSloan School of Management.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineering.en_US
dc.contributor.departmentLeaders for Global Operations Program.en_US
dc.identifier.oclc921410951en_US


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