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dc.contributor.advisorJeff Gore.en_US
dc.contributor.authorYurtsev, Evgeneen_US
dc.contributor.otherMassachusetts Institute of Technology. Department of Physics.en_US
dc.date.accessioned2015-10-14T15:03:10Z
dc.date.available2015-10-14T15:03:10Z
dc.date.copyright2015en_US
dc.date.issued2015en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/99284
dc.descriptionThesis: Ph. D., Massachusetts Institute of Technology, Department of Physics, 2015.en_US
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (pages 132-138).en_US
dc.description.abstractThrough a combination of experiments and modeling, I explored how inactivation of antibiotics by antibiotic-resistant bacteria affects the evolution of antibiotic resistance in two simple microbial communities. First, I examined the interaction between a resistant strain and a sensitive strain of the bacteria Escherichia coli in the presence of the [beta]-lactam antibiotic ampicillin. Second, I investigated whether two strains of Escherichia coli can form a cross-protection mutualism in a multi-drug environment containing the antibiotics ampicillin and chloramphenicol. In both experimental systems, I found that inactivation of antibiotics by resistant bacteria is an important cooperative behavior which enables microbes to help each other survive in otherwise lethal antibiotic concentrations. The rich dynamical behaviors that arise even in these simple systems highlight the inherent challenge in deciphering the workings of more complex microbial communities.en_US
dc.description.statementofresponsibilityby Evgene Yurtsev.en_US
dc.format.extent138 pagesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582en_US
dc.subjectPhysics.en_US
dc.titleCooperative behaviors in the evolution of antibiotic resistanceen_US
dc.typeThesisen_US
dc.description.degreePh. D.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physics
dc.identifier.oclc922884934en_US


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