Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst
Author(s)Skrydstrup, Troels; Friis, Stig; Buchwald, Stephen Leffler
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A palladacyclic precatalyst is employed to cleanly generate a highly active XantPhos-ligated Pd-catalyst. Its use in low temperature aminocarbonylations of (hetero)aryl bromides provides access to a range of challenging products in good to excellent yields with low catalyst loading and only a slight excess of CO. Some products are unattainable by traditional carbonylative coupling.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Friis, Stig D., Troels Skrydstrup, and Stephen L. Buchwald. “Mild Pd-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides with a Palladacycle Precatalyst.” Organic Letters 16, no. 16 (August 15, 2014): 4296–4299. © 2014 American Chemical Society
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