2026-09-18T22:32:18Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1008852022-01-13T07:54:05Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Alexander H. Slocum.
Sondej, Nicholas Matti
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2016-01-15T21:10:54Z
2016-01-15T21:10:54Z
2014
2014
http://hdl.handle.net/1721.1/100885
933609980
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 107).
A process and physical system were developed to manufacture pharmaceutical tablets through an electrospinning operation and subsequent compaction. Theoretical simulations of the electrospinning were run to predict physical system performance, and a proof-of-concept device was designed, produced and tested. The process was demonstrated to be theoretically scalable to levels of production suitable for industrial pharmaceutical manufacturing. The system demonstrated clear advantages over preexisting pharmaceutical manufacturing equipment, eliminating airborne drug particulate matter, minimizing liquid drying time, and enabling a more agile, liquid-based continuous manufacturing process to be utilized for pharmaceutical production. Future work was specified to refine and optimize the process, and improve process control and monitoring in order to meet the pharmaceutical industry's strict regulatory controls.
by Nicholas Matti Sondej.
S.M.
107 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Direct tablet formation by electrospinning and compaction
Thesis
application/pdf
false
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="ef02bbcb-8a8e-4927-8524-ec365a83b0ef">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Direct tablet formation by electrospinning and compaction</Title>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2014</PublicationDate>
<Authors>
<Author>
<DisplayName>Sondej, Nicholas Matti</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Mechanical Engineering.</Keyword>
<Abstract>A process and physical system were developed to manufacture pharmaceutical tablets through an electrospinning operation and subsequent compaction. Theoretical simulations of the electrospinning were run to predict physical system performance, and a proof-of-concept device was designed, produced and tested. The process was demonstrated to be theoretically scalable to levels of production suitable for industrial pharmaceutical manufacturing. The system demonstrated clear advantages over preexisting pharmaceutical manufacturing equipment, eliminating airborne drug particulate matter, minimizing liquid drying time, and enabling a more agile, liquid-based continuous manufacturing process to be utilized for pharmaceutical production. Future work was specified to refine and optimize the process, and improve process control and monitoring in order to meet the pharmaceutical industry's strict regulatory controls.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>