2026-09-19T11:39:32Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1018132022-01-13T07:54:05Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Ian W. Hunter.
Demas, Nickolas Peter
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2016-03-25T13:37:25Z
2016-03-25T13:37:25Z
2015
2015
http://hdl.handle.net/1721.1/101813
941273563
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 131-135).
Medical jet injection, in which a narrow fluid drug stream is propelled into the skin without a needle, was first conceived in the 1940s [1]. However, a major drawback of most injectors is the lack of controllability of jet parameters. Recent work at the BioInstrumentation Laboratory at MIT has resulted in a tunable, high-performance linear Lorentz-force jet injector which allows for careful control of many injection variables. The sensor presented in this thesis further improves the ability to quantify and control contact forces between the injection nozzle and tissue. This sensor uses a three-spoke flexure system with full-bridge strain gauge assemblies mounted on each flexural arm to measure both normal and lateral forces applied to the nozzle. The design, fabrication, calibration, and validation for the sensor are detailed along with results for preliminary tissue injections into ex vivo porcine tissue. These preliminary tests showed higher percent volume delivery to the tissue with an elevated normal force. Under normal forces of 4 to 8 N, the BioInstrumentation Lab's jet injector achieved percent volume delivery of 89.1 ± 5.1%, whereas with normal forces of 0 to 4 N, the percent volume delivery was 68.9 ± 12.7%.
by Nickolas Peter Demas.
S.M.
135 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
A contact force sensor for medical jet injection
Thesis
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<Abstract>Medical jet injection, in which a narrow fluid drug stream is propelled into the skin without a needle, was first conceived in the 1940s [1]. However, a major drawback of most injectors is the lack of controllability of jet parameters. Recent work at the BioInstrumentation Laboratory at MIT has resulted in a tunable, high-performance linear Lorentz-force jet injector which allows for careful control of many injection variables. The sensor presented in this thesis further improves the ability to quantify and control contact forces between the injection nozzle and tissue. This sensor uses a three-spoke flexure system with full-bridge strain gauge assemblies mounted on each flexural arm to measure both normal and lateral forces applied to the nozzle. The design, fabrication, calibration, and validation for the sensor are detailed along with results for preliminary tissue injections into ex vivo porcine tissue. These preliminary tests showed higher percent volume delivery to the tissue with an elevated normal force. Under normal forces of 4 to 8 N, the BioInstrumentation Lab's jet injector achieved percent volume delivery of 89.1 ± 5.1%, whereas with normal forces of 0 to 4 N, the percent volume delivery was 68.9 ± 12.7%.</Abstract>
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