2026-09-19T11:16:05Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1034412022-01-13T07:53:55Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Ibrahim I. Cissé.
Zhang, Lyndon N. (Lyndon Nuoxi)
Massachusetts Institute of Technology. Department of Biology.
Massachusetts Institute of Technology. Department of Biology
2016-07-01T18:24:24Z
2016-07-01T18:24:24Z
2016
2016
http://hdl.handle.net/1721.1/103441
952599982
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2016.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 29-30).
The control of transcription represents a fundamental, initial mechanism by which the regulation of gene expression is implemented. However, while much research has been done on the biochemistry and cellular function of transcription, comparatively little is known on the dynamics of transcriptional mechanisms, their impact on chromatin structure, and concomitant functional consequences. Employing chromatin immunoprecipitation measurements, we report progress towards this goal. We characterize the ensemble chromosome conformation in mouse embryonic stem cells, by measuring interaction, or contact, probabilities between distal genomic loci. We map and describe chromosome loops, consisting of two interacting CTCF sites co-bound by cohesin, that maintain the expression of genes known to promote cell identity, and restrict the expression of genes specifying repressed developmental lineages.
by Lyndon N. Zhang.
S.M.
30 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Biology.
Conformation and dynamics of the mammalian chromosome
Thesis
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