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Dennis M. Freeman. Page, Scott Lawrence Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science 2016-07-18T20:05:31Z 2016-07-18T20:05:31Z 2016 2016 http://hdl.handle.net/1721.1/103740 953525187 Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016. Cataloged from PDF version of thesis. Includes bibliographical references (pages 103-112). Extraordinary sensitivity, frequency selectivity, and dynamic range are hallmarks of mammalian hearing. While a variety of cellular and molecular mechanisms are known to be critical to these properties, how the cellular and molecular mechanisms interact to generate the remarkable properties remains unclear. Direct observations of these interacts has proved to be difficult, in large part because the inner ear is fragile and has been difficult to probe with conventional measurement technologies. We have developed an Optical Coherence Tomography (OCT) system to use light to probe both the structure and mechanical responses of the inner ear to sound stimulation. The technique takes advantage of the interference of low coherence sources of light to detect even weakly scattering tissues in the inner ear. By sensing Doppler shifts of light scattered off moving structures in the inner ear, the OCT system can also detect sound-induced motions of cochlear structures with sub-nanometer resolution. This thesis demonstrates the use of the OCT system to study the structure of the inner ears of mice, gerbils, and guinea pigs, as well as the acoustic response of the apical turn of in vitro and in vivo apical mammalian cochleae to low frequency (100 to 1000 Hz) sounds - frequencies that are critical to our understanding of speech. by Scott Lawrence Page. Ph.D. 112 pages eng Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Electrical Engineering and Computer Science. Cochlear morphology and sound-induced motion of the apical mammalian inner ear Thesis application/pdf Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="1dcf5832-1df1-424d-a776-044ea04941cc"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Cochlear morphology and sound-induced motion of the apical mammalian inner ear</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2016</PublicationDate> <Authors> <Author> <DisplayName>Page, Scott Lawrence</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Electrical Engineering and Computer Science.</Keyword> <Abstract>Extraordinary sensitivity, frequency selectivity, and dynamic range are hallmarks of mammalian hearing. While a variety of cellular and molecular mechanisms are known to be critical to these properties, how the cellular and molecular mechanisms interact to generate the remarkable properties remains unclear. Direct observations of these interacts has proved to be difficult, in large part because the inner ear is fragile and has been difficult to probe with conventional measurement technologies. We have developed an Optical Coherence Tomography (OCT) system to use light to probe both the structure and mechanical responses of the inner ear to sound stimulation. The technique takes advantage of the interference of low coherence sources of light to detect even weakly scattering tissues in the inner ear. By sensing Doppler shifts of light scattered off moving structures in the inner ear, the OCT system can also detect sound-induced motions of cochlear structures with sub-nanometer resolution. This thesis demonstrates the use of the OCT system to study the structure of the inner ears of mice, gerbils, and guinea pigs, as well as the acoustic response of the apical turn of in vitro and in vivo apical mammalian cochleae to low frequency (100 to 1000 Hz) sounds - frequencies that are critical to our understanding of speech.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>