2026-09-20T03:49:13Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1041432022-01-13T07:54:05Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
David E. Hardt.
Chamberlain, Peter T. (Peter Thomas)
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2016-09-13T18:09:30Z
2016-09-13T18:09:30Z
2016
2016
http://hdl.handle.net/1721.1/104143
958163194
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 150-151).
Microfluidics are becoming commonplace in research and medicine, particularly in point-of-care diagnostics and drug development. Many manufacturing methods exist for such devices, but initial setup can be costly and slow, hindering the ability to quickly iterate on designs. Hot embossing has previously been demonstrated to have low capital costs and high flexibility. This work focuses on leveraging this flexibility to implement a closed-loop feedback controller within an automated hot embossing manufacturing cell. Three families of controllers are implemented and analyzed for compatibility with this system. The first is based on a classic discrete integral controller. The second extends this work by developing a method for optimizing the system outputs. The third combines statistical methods and traditional process control to suit the non-linear embossing process. Finally, preliminary experiments demonstrate the ability of the hot embossing system to replicate nano-scale features, providing the future opportunity to manufacture nanofluidic devices with the same equipment and methodology as microfluidic devices.
by Peter T. Chamberlain.
S.M.
156 pages
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Rapid & controlled manufacturing of microfluidic devices using hot embossing
Rapid and controlled manufacturing of microfluidic devices using hot embossing
Thesis
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<Abstract>Microfluidics are becoming commonplace in research and medicine, particularly in point-of-care diagnostics and drug development. Many manufacturing methods exist for such devices, but initial setup can be costly and slow, hindering the ability to quickly iterate on designs. Hot embossing has previously been demonstrated to have low capital costs and high flexibility. This work focuses on leveraging this flexibility to implement a closed-loop feedback controller within an automated hot embossing manufacturing cell. Three families of controllers are implemented and analyzed for compatibility with this system. The first is based on a classic discrete integral controller. The second extends this work by developing a method for optimizing the system outputs. The third combines statistical methods and traditional process control to suit the non-linear embossing process. Finally, preliminary experiments demonstrate the ability of the hot embossing system to replicate nano-scale features, providing the future opportunity to manufacture nanofluidic devices with the same equipment and methodology as microfluidic devices.</Abstract>
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