2026-09-20T02:19:44Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1117272022-01-13T07:54:05Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Alexander Slocum.
Labib, Shahd Hassan
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2017-10-04T15:05:42Z
2017-10-04T15:05:42Z
2017
http://hdl.handle.net/1721.1/111727
1004237382
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, June 2017.
"May 2017." Cataloged from PDF version of thesis.
Includes bibliographical references (pages 226-229).
Nanofiber fabrication of pharmaceutical pills creates significant advantages over conventional techniques such as shorter pill dissolution times, airborne drug particulate matter elimination, and shorter liquid drying time, among many others. Therefore, the Novartis MIT Center for Continuous Manufacturing is prioritizing development of electrospinning techniques for producing nanofibrous pills. However, electrospinning pills still has a very low production rate compared to that of the current pharmaceutical techniques. Motivated by the need for an efficient and effective elecrospinning technique, we developed the "Spin, Strip, and Stomp Mechanism." This technique has successfully made pills of the required quality, designed with the goal of reducing the gap between the low production rates of nanofibrous pills and the high rates of the current pill making techniques.
by Shahd Hassan Labib.
S.M.
229 pages
eng
Massachusetts Institute of Technology
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Designing, building, and testing the spin, strip, and stomp mechanism for pharmaceutical tableting
Thesis
application/pdf
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Publication
unknown
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<Abstract>Nanofiber fabrication of pharmaceutical pills creates significant advantages over conventional techniques such as shorter pill dissolution times, airborne drug particulate matter elimination, and shorter liquid drying time, among many others. Therefore, the Novartis MIT Center for Continuous Manufacturing is prioritizing development of electrospinning techniques for producing nanofibrous pills. However, electrospinning pills still has a very low production rate compared to that of the current pharmaceutical techniques. Motivated by the need for an efficient and effective elecrospinning technique, we developed the "Spin, Strip, and Stomp Mechanism." This technique has successfully made pills of the required quality, designed with the goal of reducing the gap between the low production rates of nanofibrous pills and the high rates of the current pill making techniques.</Abstract>
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