2026-09-20T23:32:09Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1129032026-06-06T00:49:28Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Peter Sorger and Doug Lauffenberger.
Cunningham, Joseph M., M. Eng. Massachusetts Institute of Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
2017-12-20T18:16:43Z
2017-12-20T18:16:43Z
2017
2017
http://hdl.handle.net/1721.1/112903
1015201724
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 29-31).
Protein-protein interactions are one of the cornerstones of biological processes throughout the cell. Unfortunately, lack of available data precludes many possible approaches to modeling these fundamental interactions at scale. This thesis focuses on a specific set of protein domains, known as peptide-binding domains (PBD), that play a particularly crucial role in mediating protein-protein interactions. Using these components as a basis, we develop a model for protein-protein interactions driven by PBDs. Our approach revises a previously proposed model, both expanding its applicability to a much larger set of PBDs and improving the performance of the model. We conclude with an application of our model that shows the flexibility of our approach.
by Joseph M. Cunningham.
M.Eng.
36 pages
eng
Massachusetts Institute of Technology
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
http://dspace.mit.edu/handle/1721.1/7582
Electrical Engineering and Computer Science.
Protein potentials and domains : re-use and composability
Thesis
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