2026-09-21T08:30:06Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1156462022-01-13T07:53:53Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Wesley Harris.
Atsaves, Louis
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics.
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics
2018-05-23T16:28:31Z
2018-05-23T16:28:31Z
2018
2018
http://hdl.handle.net/1721.1/115646
1036984727
Thesis: S.M., Massachusetts Institute of Technology, Department of Aeronautics and Astronautics, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 39).
Sickle-cell diseased persons suffer finite pain episodes (luring their lifetime, which are termed sickle cell crises. Using a sickle cell blood flow model, we mathematically demonstrate that the onset of a sickle cell crisis is chaotic. We further show that sickle cell crises may be mitigated by manipulating certain physiological parameters, namely the partial pressure of oxygen at 50% hemoglobin ([mathematical formula]%) and the kinetic dissociation rate of hemoglobin (kub) These physiological parameters control the chaotic nature of sickle cell crises and have the ability to transfer a person from a crisis state to a non-crisis state. We determine that sickle cell crises may only be mitigated within a critical time period (0 </- t </- 2.5hrs) after the onset of a sickle cell crisis. Based on our analysis, we classify three stages of a sickle cell crisis as weak chaos, strong chaos, and hyperchaos; which range from light to intense pain. Drugs may be developed, based on our analysis, to target these physiological parameters and mitigate sickle cell crises at its onset.
by Louis Atsaves.
S.M.
39 pages
eng
Massachusetts Institute of Technology
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
http://dspace.mit.edu/handle/1721.1/7582
Aeronautics and Astronautics.
Mitigation of sickle cell crises using chaos-based analysis
Thesis
application/pdf
false
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="8691924f-951b-4dc6-bfdc-03d5749217bd">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Mitigation of sickle cell crises using chaos-based analysis</Title>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2018</PublicationDate>
<Authors>
<Author>
<DisplayName>Atsaves, Louis</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Aeronautics and Astronautics.</Keyword>
<Abstract>Sickle-cell diseased persons suffer finite pain episodes (luring their lifetime, which are termed sickle cell crises. Using a sickle cell blood flow model, we mathematically demonstrate that the onset of a sickle cell crisis is chaotic. We further show that sickle cell crises may be mitigated by manipulating certain physiological parameters, namely the partial pressure of oxygen at 50% hemoglobin ([mathematical formula]%) and the kinetic dissociation rate of hemoglobin (kub) These physiological parameters control the chaotic nature of sickle cell crises and have the ability to transfer a person from a crisis state to a non-crisis state. We determine that sickle cell crises may only be mitigated within a critical time period (0 </- t </- 2.5hrs) after the onset of a sickle cell crisis. Based on our analysis, we classify three stages of a sickle cell crisis as weak chaos, strong chaos, and hyperchaos; which range from light to intense pain. Drugs may be developed, based on our analysis, to target these physiological parameters and mitigate sickle cell crises at its onset.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>