2026-09-19T15:45:57Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1190682022-01-13T07:55:22Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Michael S. Strano.
Sun, Jessica H
Massachusetts Institute of Technology. Department of Materials Science and Engineering.
Massachusetts Institute of Technology. Department of Materials Science and Engineering
2018-11-15T16:35:12Z
2018-11-15T16:35:12Z
2018
2018
http://hdl.handle.net/1721.1/119068
1057894392
Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 32-34).
Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil.
by Jessica H. Sun.
S.B.
34 pages
eng
Massachusetts Institute of Technology
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
http://dspace.mit.edu/handle/1721.1/7582
Materials Science and Engineering.
Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes
Thesis
application/pdf
Publication
unknown
unknown
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<Abstract>Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil.</Abstract>
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