2026-09-20T02:19:43Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1197692026-06-16T18:54:53Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Ian W. Hunter.
Modak, Ashin (Ashin Pramod)
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2018-12-18T20:03:53Z
2018-12-18T20:03:53Z
2018
2018
http://hdl.handle.net/1721.1/119769
1078146815
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 137-143).
Negative pressure wound therapy (NPWT) is a commonly used treatment in which the application of a low vacuum (-20kPa) is used to accelerate the recovery of chronic, hard-to-heal wounds. Costs of chronic wounds such as diabetic foot ulcers are estimated to be $25 billion, with 6.5 million patients being affected. Improving the portability and efficacy of NPWT devices will allow a larger migration of patients from hospital stays to at-home care. Current portable NPWT devices have severe limitations due to their size, inability to dynamically modulate pressure or handle large volumes of wound exudate. The work in this thesis was to develop a more portable NPWT device in which all functional components are self-contained within the bandage itself. To accomplish this goal, a soft-material, fuel-cell based actuator was designed and incorporated into a self contained, compact pumping mechanism. Additionally graphene-oxide barriers were designed to allow for fluid management at the wound site. The designed bandage was able to maintain negative pressure even at worst-case scenario leak rates (6.7 x 102 mL/s) and an exudate rate of 5.6 x 10-5 mL/s. The contributions from this thesis are a novel, soft-materials based actuator for use in biomedical applications and the further characterization of graphene-oxide barriers.
by Ashin Modak.
Ph.D.
143 pages
eng
Massachusetts Institute of Technology
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Design and development of a smart, self-contained, portable negative pressure wound therapy device
Thesis
application/pdf
false
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="46251aaf-8591-4621-8d98-bbe21157f512">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Design and development of a smart, self-contained, portable negative pressure wound therapy device</Title>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2018</PublicationDate>
<Authors>
<Author>
<DisplayName>Modak, Ashin (Ashin Pramod)</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Mechanical Engineering.</Keyword>
<Abstract>Negative pressure wound therapy (NPWT) is a commonly used treatment in which the application of a low vacuum (-20kPa) is used to accelerate the recovery of chronic, hard-to-heal wounds. Costs of chronic wounds such as diabetic foot ulcers are estimated to be $25 billion, with 6.5 million patients being affected. Improving the portability and efficacy of NPWT devices will allow a larger migration of patients from hospital stays to at-home care. Current portable NPWT devices have severe limitations due to their size, inability to dynamically modulate pressure or handle large volumes of wound exudate. The work in this thesis was to develop a more portable NPWT device in which all functional components are self-contained within the bandage itself. To accomplish this goal, a soft-material, fuel-cell based actuator was designed and incorporated into a self contained, compact pumping mechanism. Additionally graphene-oxide barriers were designed to allow for fluid management at the wound site. The designed bandage was able to maintain negative pressure even at worst-case scenario leak rates (6.7 x 102 mL/s) and an exudate rate of 5.6 x 10-5 mL/s. The contributions from this thesis are a novel, soft-materials based actuator for use in biomedical applications and the further characterization of graphene-oxide barriers.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>