2026-09-20T10:43:39Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1228582026-06-17T14:44:46Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Timothy F. Jamison.
Weber, Jessica M.(Jessica Marie)
Massachusetts Institute of Technology. Department of Chemistry.
Massachusetts Institute of Technology. Department of Chemistry
2019-11-12T17:39:34Z
2019-11-12T17:39:34Z
2019
2019
https://hdl.handle.net/1721.1/122858
1126333828
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019
Cataloged from PDF version of thesis. Page 393 blank.
Includes bibliographical references.
[color illustrations] We introduce a new class of bench-stable N-heterocyclic carbene nickel precatalysts for homogeneous nickel-catalysis. The nickel(II) complexes are readily activated to Ni⁰ in situ under mild conditions, via a proposed Heck-type mechanism. The precatalysts are able to facilitate carbonyl-ene, hydroalkenylation, and amination reactions. [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable triphenylphosphine nickel(II) precatalysts, which activate through a Heck-type mechanism. The activity of these precatalysts is demonstrated with a carbonyl-ene coupling reaction.
by Jessica M. Weber.
Ph.D.
Ph.D. Massachusetts Institute of Technology, Department of Chemistry
393 pages
eng
Massachusetts Institute of Technology
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
http://dspace.mit.edu/handle/1721.1/7582
Chemistry.
Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
Thesis
application/pdf
2019-11-12T17:39:32Z
Publication
Doctoral
Chem
unknown
unknown
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<Abstract>[color illustrations] We introduce a new class of bench-stable N-heterocyclic carbene nickel precatalysts for homogeneous nickel-catalysis. The nickel(II) complexes are readily activated to Ni⁰ in situ under mild conditions, via a proposed Heck-type mechanism. The precatalysts are able to facilitate carbonyl-ene, hydroalkenylation, and amination reactions. [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable triphenylphosphine nickel(II) precatalysts, which activate through a Heck-type mechanism. The activity of these precatalysts is demonstrated with a carbonyl-ene coupling reaction.</Abstract>
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