2026-09-20T03:48:37Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1279172021-07-05T14:03:20Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Alexander H. Slocum.
Flores, Ryan Maximiliano.
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2020-10-08T21:30:18Z
2020-10-08T21:30:18Z
2020
2020
https://hdl.handle.net/1721.1/127917
1197727845
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 61-62).
The process of unit dose continuous lyophilization consists of moving vials containing unit doses of pharmaceutical product though a series of process chambers with varying pressures and temperatures. In order to move the vials between process chambers with varying pressures without disturbing the conditions within each respective chamber, a load lock is required. Although load locks are commonly used in the semiconductor industry, existing designs are not directly applicable to the unit dose continuous lyophilization process due to the unique geometric constraints on the system. This thesis document details the design of a load-lock door for the unit dose continuous lyophilization process. To meet the load-lock door functional requirements, a four-bar linkage load-lock door and a load-lock door with ground pivots offset from the sealing surface were designed. Because the driving performance parameters cannot be reliably modeled, the seal performance, particle generation, and seal adhesion of each design will be experimentally tested. The highest performing design will be chosen and improved based on the experimental results.
by Ryan Maximiliano Flores.
S.B.
S.B. Massachusetts Institute of Technology, Department of Mechanical Engineering
62 pages
eng
Massachusetts Institute of Technology
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Design of load-lock door for unit dose continuous lyophilization process for complex biologics
Thesis
application/pdf
2020-10-08T21:30:17Z
Publication
Bachelor
MechE
unknown
unknown
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<Abstract>The process of unit dose continuous lyophilization consists of moving vials containing unit doses of pharmaceutical product though a series of process chambers with varying pressures and temperatures. In order to move the vials between process chambers with varying pressures without disturbing the conditions within each respective chamber, a load lock is required. Although load locks are commonly used in the semiconductor industry, existing designs are not directly applicable to the unit dose continuous lyophilization process due to the unique geometric constraints on the system. This thesis document details the design of a load-lock door for the unit dose continuous lyophilization process. To meet the load-lock door functional requirements, a four-bar linkage load-lock door and a load-lock door with ground pivots offset from the sealing surface were designed. Because the driving performance parameters cannot be reliably modeled, the seal performance, particle generation, and seal adhesion of each design will be experimentally tested. The highest performing design will be chosen and improved based on the experimental results.</Abstract>
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