2026-09-19T21:35:03Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1279292021-07-05T14:03:20Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Alexander H. Slocum.
Le, Serena.
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2020-10-08T21:30:52Z
2020-10-08T21:30:52Z
2020
2020
https://hdl.handle.net/1721.1/127929
1197978944
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 65-66).
Lyophilization, or freeze drying, of unit-dose pharmaceuticals eliminates the need to preserve quality through regulated temperature storage during transport. Typical lyophilization is performed through batch processing, but implementing continuous manufacturing instead can lead to improved process control, higher quality product, and increased flexibility. Lyophilization involves four processing chambers at specific pressures and transferring vials between the chambers requires a load lock system. Load lock systems, commonly used in the semiconductor industry, act as a transfer chamber in order to reduce pump-down and venting time of its adjacent processing chambers. This thesis documents the research and design of a load lock system for a continuous manufacturing lyophilization machine.
by Serena Le.
S.B.
S.B. Massachusetts Institute of Technology, Department of Mechanical Engineering
66 pages
eng
Massachusetts Institute of Technology
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine
Thesis
application/pdf
2020-10-08T21:30:51Z
Publication
Bachelor
MechE
unknown
unknown
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<Abstract>Lyophilization, or freeze drying, of unit-dose pharmaceuticals eliminates the need to preserve quality through regulated temperature storage during transport. Typical lyophilization is performed through batch processing, but implementing continuous manufacturing instead can lead to improved process control, higher quality product, and increased flexibility. Lyophilization involves four processing chambers at specific pressures and transferring vials between the chambers requires a load lock system. Load lock systems, commonly used in the semiconductor industry, act as a transfer chamber in order to reduce pump-down and venting time of its adjacent processing chambers. This thesis documents the research and design of a load lock system for a continuous manufacturing lyophilization machine.</Abstract>
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