2026-09-20T10:22:15Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1283382021-07-05T14:03:20Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Kripa K. Varanasi.
Jayaprakash, Vishnu.
Massachusetts Institute of Technology. Department of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2020-11-03T20:31:41Z
2020-11-03T20:31:41Z
2019
2019
https://hdl.handle.net/1721.1/128338
1201697608
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, June, 2019
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 31-32).
High concentration drug formulations that can be delivered via subcutaneous injections offer tremendous benefits to global health, but their high viscosity prevents injectability through medical needles. Current approaches to solve this problem face several challenges ranging from cross contamination and high cost to needle clogging and protein inactivation. Here we report a simple method to enhance formulation injectability through a core annular flow that lubricates viscous transport through a needle. We study the importance of different flow regimes and density based eccentricity in dictating lubrication in the needle. Finally, we quantify the maximum pressure reduction that can be achieved with such a lubricating core annular flow.
by Vishnu Jayaprakash.
S.M.
S.M. Massachusetts Institute of Technology, Department of Mechanical Engineering
32 pages
eng
Massachusetts Institute of Technology
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Enhancing the injectability of high concentration drugs via core annular flows
Thesis
application/pdf
2020-11-03T20:31:40Z
Publication
Master
MechE
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="0e9aad1b-62e1-4fd0-9c5f-51cd8f6c10b3">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Enhancing the injectability of high concentration drugs via core annular flows</Title>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2019</PublicationDate>
<Authors>
<Author>
<DisplayName>Jayaprakash, Vishnu.</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Mechanical Engineering.</Keyword>
<Abstract>High concentration drug formulations that can be delivered via subcutaneous injections offer tremendous benefits to global health, but their high viscosity prevents injectability through medical needles. Current approaches to solve this problem face several challenges ranging from cross contamination and high cost to needle clogging and protein inactivation. Here we report a simple method to enhance formulation injectability through a core annular flow that lubricates viscous transport through a needle. We study the importance of different flow regimes and density based eccentricity in dictating lubrication in the needle. Finally, we quantify the maximum pressure reduction that can be achieved with such a lubricating core annular flow.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>