2026-09-20T20:15:12Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1299212026-06-06T00:55:23Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Martin C. Rinard.
McCleary, Jennifer(Jennifer A.)
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
2021-02-19T20:58:01Z
2021-02-19T20:58:01Z
2020
2020
https://hdl.handle.net/1721.1/129921
1237530441
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, February, 2020
Cataloged from student-submitted PDF of thesis.
Includes bibliographical references (pages 67-74).
Pancreatic cancer is the third most lethal cancer in the U.S., causing an estimated 45,750 deaths in 2019. Of all treatments, surgical resection provides the best survival rate for pancreatic cancer. This is not feasible for the majority of pancreatic cancer patients, whose cancer is typically not diagnosed until the tumor is unresectable. Most symptoms of pancreatic cancer are typically subtle, which underscores the need for better risk modeling to predict a patient's chance of pancreatic cancer well before it would usually be diagnosed. We propose a series of novel models that apply standard machine learning techniques to Electronic Health Records (EHRs) to predict risk of pancreatic cancer in advance of cancer diagnosis. On the test dataset, two of our models achieved AUROCs of 0.85 (CI 0.81 - 0.90) and 0.79 (CI 0.77 - 0.82) with a 365-day lead time.
by Jennifer McCleary.
M.Eng.
M.Eng. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
74 pages
eng
Massachusetts Institute of Technology
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
http://dspace.mit.edu/handle/1721.1/7582
Electrical Engineering and Computer Science.
Learning risk models for pancreatic cancer from electronic health records
Thesis
application/pdf
2021-02-19T20:57:31Z
Publication
Master
EECS
unknown
unknown
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<Abstract>Pancreatic cancer is the third most lethal cancer in the U.S., causing an estimated 45,750 deaths in 2019. Of all treatments, surgical resection provides the best survival rate for pancreatic cancer. This is not feasible for the majority of pancreatic cancer patients, whose cancer is typically not diagnosed until the tumor is unresectable. Most symptoms of pancreatic cancer are typically subtle, which underscores the need for better risk modeling to predict a patient's chance of pancreatic cancer well before it would usually be diagnosed. We propose a series of novel models that apply standard machine learning techniques to Electronic Health Records (EHRs) to predict risk of pancreatic cancer in advance of cancer diagnosis. On the test dataset, two of our models achieved AUROCs of 0.85 (CI 0.81 - 0.90) and 0.79 (CI 0.77 - 0.82) with a 365-day lead time.</Abstract>
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