2026-09-19T08:53:31Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1306762026-06-16T18:55:14Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Polina Anikeeva.
Moon, Junsang.
Massachusetts Institute of Technology. Department of Materials Science and Engineering.
Massachusetts Institute of Technology. Department of Materials Science and Engineering
2021-05-24T19:40:06Z
2021-05-24T19:40:06Z
2021
2021
https://hdl.handle.net/1721.1/130676
1251770341
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Materials Science and Engineering, February, 2021
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 137-147).
Understanding the structure and dynamics of the mammalian cellular signaling and the nervous system opens up the chances to induce tissues, organs, or organisms to function in a coordinated way. Consequently, extensive research and efforts have rapidly developed strategies for rationally manipulating cellular and neuronal signaling. In this thesis, I pursued to develop a wirelessly modulating system that can selectively control a targeted biological circuit. Heat dissipating properties of magnetic nanoparticles have garnered sustained research interest in biomedical applications, including drug release, cancer hyperthermia, and neural stimulations. However, research has been mainly focused on improving the magnetic nanomaterials' heat dissipation efficiency. To introduce selective heat dissipation of magnetic nanoparticles, I have designed a custom AC magnetometer that can capture dynamic magnetization of magnetic particles suspended in solution. The collected magnetic response data fed to an equation called multiplexing factor to find optimized alternative magnetic field conditions that can selectively trigger heat dissipation on each particle ensemble. This approach was confirmed by direct temperature change observation using a thermographic camera. The selective heating system was later combined with genetic engineering and a drug delivery system for selective cellular modulation. This work culminates in a demonstration of selective remote control of cellular signaling in vitro. The theoretical background, systematic design, and precisely executed demonstration can be transplanted to any system using magnetic nanoparticles as a heat transducer. Therefore, this study will set a strong foundation and suggest new approaches for researches utilizing magnetic nanoparticle's heat dissipation for any applications.
by Junsang Moon.
Ph.D.
Ph.D. Massachusetts Institute of Technology, Department of Materials Science and Engineering
147 pages
eng
Massachusetts Institute of Technology
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
http://dspace.mit.edu/handle/1721.1/7582
Materials Science and Engineering.
Design for selective remote control of cellular signaling using magnetic nanoparticles
Thesis
application/pdf
2021-05-24T19:40:06Z
Publication
Doctoral
MatSci
unknown
unknown
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