2026-09-20T09:09:01Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1449302022-08-30T04:09:17Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Buchwald, Stephen L.
Feng, Sheng
Massachusetts Institute of Technology. Department of Chemistry
2022-08-29T16:21:45Z
2022-08-29T16:21:45Z
2022-05
2022-06-08T13:04:36.615Z
https://hdl.handle.net/1721.1/144930
0000-0001-8781-9681
The work described in this dissertation focuses on developing copper(I) hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. The third chapter demonstrates the enantioselective hydrocarbamoylation of alkenes enable by dual CuH and Pd catalysis.
Ph.D.
Massachusetts Institute of Technology
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http://rightsstatements.org/page/InC-EDU/1.0/
Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions
Thesis
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Doctoral
Doctor of Philosophy
Publication
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<Abstract>The work described in this dissertation focuses on developing copper(I) hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. The third chapter demonstrates the enantioselective hydrocarbamoylation of alkenes enable by dual CuH and Pd catalysis.</Abstract>
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