<?xml version="1.0" encoding="UTF-8"?><?xml-stylesheet type="text/xsl" href="static/style.xsl"?><OAI-PMH xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd"><responseDate>2026-09-20T12:12:30Z</responseDate><request verb="GetRecord" identifier="oai:dspace.mit.edu:1721.1/147365" metadataPrefix="dim">https://dspace.mit.edu/server/oai/request</request><GetRecord><record><header><identifier>oai:dspace.mit.edu:1721.1/147365</identifier><datestamp>2023-01-20T03:01:00Z</datestamp><setSpec>com_1721.1_7582</setSpec><setSpec>com_1721.1_7581</setSpec><setSpec>col_1721.1_131022</setSpec></header><metadata><dim:dim xmlns:dim="http://www.dspace.org/xmlns/dspace/dim" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.dspace.org/xmlns/dspace/dim http://www.dspace.org/schema/dim.xsd">
   <dim:field mdschema="dc" element="contributor" qualifier="advisor">Winslow, Lindley</dim:field>
   <dim:field mdschema="dc" element="contributor" qualifier="advisor">Ma, Tammy</dim:field>
   <dim:field mdschema="dc" element="contributor" qualifier="author">Simpson, Raspberry</dim:field>
   <dim:field mdschema="dc" element="contributor" qualifier="department">Massachusetts Institute of Technology. Department of Nuclear Science and Engineering</dim:field>
   <dim:field mdschema="dc" element="date" qualifier="accessioned">2023-01-19T18:48:26Z</dim:field>
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   <dim:field mdschema="dc" element="date" qualifier="issued">2022-09</dim:field>
   <dim:field mdschema="dc" element="date" qualifier="submitted">2022-10-12T19:35:09.877Z</dim:field>
   <dim:field mdschema="dc" element="identifier" qualifier="uri">https://hdl.handle.net/1721.1/147365</dim:field>
   <dim:field mdschema="dc" element="description" qualifier="abstract">Since the innovation of chirped pulse amplification by Donna Strickland and Gerard Morou in 1985, laser technology has evolved such that we can create short pulses of light (10⁻¹⁵ − 10⁻¹² seconds) with high peak powers (1015 Watts) in small, focused spots (∼a few microns). A prolific area of research that has emerged over the last two decades is the use of these high-intensity lasers to drive particle beams. Possible applications of these particle sources include isotope production for medical applications, proton cancer therapy, and fusion energy schemes. This thesis focuses on laser-driven proton acceleration and adds to the existing foundation of work in the area by investigating new empirical relationships, conducting new measurements of the accelerating electric field responsible for laser-driven proton acceleration, and developing a new data analysis methodology using machine learning. This work first examines laser-driven proton acceleration in the multi-picosecond regime (>1ps) at laser intensities of 10¹⁷ − 10¹⁹ W/cm². This is motivated by recent results on laser platforms like the National Ignition Facility-Advanced Radiographic Capability laser and the OMEGA-Extended Performance laser, which have demonstrated enhanced accelerated proton energies when compared to established scaling laws. A detailed scaling study was performed on the Titan laser, which provided the basis for a new analytical scaling presented in this thesis. In addition, high-repetition-rate (HRR) lasers that can operate at 1 Hz or faster are now coming online around the world, opening a myriad of opportunities for accelerating the rate of learning on laser-driven particle experiments. To unlock these applications, HRR diagnostics combined with real-time analysis tools must be developed to process experimental measurements and outputs at HRR. Towards this goal, this thesis presents a novel automated data analysis framework based on machine learning and proposes a new methodology based on representation learning to integrate heterogeneous data constrain parameters that are not directly measurable. Taken together, these thrusts enable a new preliminary framework for enhanced analysis of complex HRR experiments and a foundational step towards realizing the goal of tunable laser-driven particle sources.</dim:field>
   <dim:field mdschema="dc" element="description" qualifier="degree">Ph.D.</dim:field>
   <dim:field mdschema="dc" element="publisher">Massachusetts Institute of Technology</dim:field>
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   <dim:field mdschema="dc" element="rights">Copyright MIT</dim:field>
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   <dim:field mdschema="dc" element="title">Investigation of laser-driven particle acceleration for the development of tunable ion sources for applications in high energy density science</dim:field>
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   	&lt;Title>Investigation of laser-driven particle acceleration for the development of tunable ion sources for applications in high energy density science&lt;/Title>
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   	&lt;PublicationDate>2022-09&lt;/PublicationDate>
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   	&lt;Abstract>Since the innovation of chirped pulse amplification by Donna Strickland and Gerard Morou in 1985, laser technology has evolved such that we can create short pulses of light (10⁻¹⁵ − 10⁻¹² seconds) with high peak powers (1015 Watts) in small, focused spots (∼a few microns). A prolific area of research that has emerged over the last two decades is the use of these high-intensity lasers to drive particle beams. Possible applications of these particle sources include isotope production for medical applications, proton cancer therapy, and fusion energy schemes. This thesis focuses on laser-driven proton acceleration and adds to the existing foundation of work in the area by investigating new empirical relationships, conducting new measurements of the accelerating electric field responsible for laser-driven proton acceleration, and developing a new data analysis methodology using machine learning. This work first examines laser-driven proton acceleration in the multi-picosecond regime (&amp;gt;1ps) at laser intensities of 10¹⁷ − 10¹⁹ W/cm². This is motivated by recent results on laser platforms like the National Ignition Facility-Advanced Radiographic Capability laser and the OMEGA-Extended Performance laser, which have demonstrated enhanced accelerated proton energies when compared to established scaling laws. A detailed scaling study was performed on the Titan laser, which provided the basis for a new analytical scaling presented in this thesis. In addition, high-repetition-rate (HRR) lasers that can operate at 1 Hz or faster are now coming online around the world, opening a myriad of opportunities for accelerating the rate of learning on laser-driven particle experiments. To unlock these applications, HRR diagnostics combined with real-time analysis tools must be developed to process experimental measurements and outputs at HRR. Towards this goal, this thesis presents a novel automated data analysis framework based on machine learning and proposes a new methodology based on representation learning to integrate heterogeneous data constrain parameters that are not directly measurable. Taken together, these thrusts enable a new preliminary framework for enhanced analysis of complex HRR experiments and a foundational step towards realizing the goal of tunable laser-driven particle sources.&lt;/Abstract>
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