2026-09-19T04:36:01Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1519302026-07-31T14:59:53Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Kamm, Roger D.
Jia, Delace (Delace L.)
Massachusetts Institute of Technology. Department of Mechanical Engineering
2023-08-23T16:19:50Z
2023-08-23T16:19:50Z
2023-06
2023-07-18T16:17:20.327Z
https://hdl.handle.net/1721.1/151930
Microphysiological systems provide novel platforms for drug testing and therapeutic target discovery, through their three-dimensional morphologies that mimic specific tissues and organs. In concurrence with these systems, microfluidic channels allow for a sufficient supply of nutrients to the cell culture; by creating pressure gradients across the system, they allow for fluid flow through the tissue medium. A microfluidic pump, Microheart, for continuous flow through microphysiological systems was presented in Offeddu, 2021. The design introduced a novel, low-cost method of delivering cell culture media at low flow rates. While the Microheart pumps in practice have qualitatively provided an indication of media flow through microphysiological systems, the yield rate of production, and efficacy of their function have not been fully characterized. The following study explores the potential failure modes of the Microheart pump, and characterizes the pump consistency over the standard time of function with cell cultures.
S.B.
Massachusetts Institute of Technology
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https://rightsstatements.org/page/InC-EDU/1.0/
Characterizing Failure Modes in Continuous Flow Microfluidic Pumps
Thesis
application/pdf
Bachelor
Bachelor of Science in Mechanical Engineering
Publication
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unknown
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<Abstract>Microphysiological systems provide novel platforms for drug testing and therapeutic target discovery, through their three-dimensional morphologies that mimic specific tissues and organs. In concurrence with these systems, microfluidic channels allow for a sufficient supply of nutrients to the cell culture; by creating pressure gradients across the system, they allow for fluid flow through the tissue medium. A microfluidic pump, Microheart, for continuous flow through microphysiological systems was presented in Offeddu, 2021. The design introduced a novel, low-cost method of delivering cell culture media at low flow rates. While the Microheart pumps in practice have qualitatively provided an indication of media flow through microphysiological systems, the yield rate of production, and efficacy of their function have not been fully characterized. The following study explores the potential failure modes of the Microheart pump, and characterizes the pump consistency over the standard time of function with cell cultures.</Abstract>
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