2026-09-18T18:43:06Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1519842026-08-04T02:36:47Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Esvelt, Kevin M.
Gretton, Dana
2023-08-30T15:56:31Z
2023-08-30T15:56:31Z
2022-09
2023-08-16T20:45:25.273Z
https://hdl.handle.net/1721.1/151984
Innovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software implementation is provided and exercised in a range of applications, and hardware demonstrators have been produced.
S.M.
Massachusetts Institute of Technology
In Copyright - Educational Use Permitted
Copyright MIT
http://rightsstatements.org/page/InC-EDU/1.0/
Platforms for Biological Control
Thesis
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
application/pdf
Master
Master of Science in Media Arts and Sciences
Publication
unknown
unknown
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<Abstract>Innovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software implementation is provided and exercised in a range of applications, and hardware demonstrators have been produced.</Abstract>
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