2026-09-20T08:42:09Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1519882023-09-01T03:10:37Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Dagdeviren, Canan
Shah, Aastha
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
2023-08-30T15:57:05Z
2023-08-30T15:57:05Z
2023-06
2023-08-16T20:34:29.552Z
https://hdl.handle.net/1721.1/151988
Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, we report a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin. The cUSP consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets (0.8 cm², 1 mm deep) over larger areas of conformal contact (20 cm²). Multiphysics simulation models, acoustic spectrum analysis and high-speed videography are used to characterize transducer deflection, acoustic pressure fields and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro with a 10-minute ultrasound application, demonstrating suitability of the device for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
S.M.
Massachusetts Institute of Technology
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https://rightsstatements.org/page/InC-EDU/1.0/
A conformable ultrasound patch for cavitation enhanced transdermal cosmeceutical delivery
Thesis
application/pdf
Master
Master of Science in Media Arts and Sciences
Publication
unknown
unknown
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<Abstract>Increased consumer interest in healthy-looking skin demands a safe and effective method to increase transdermal absorption of innovative therapeutic cosmeceuticals. However, permeation of small-molecule drugs is limited by the innate barrier function of the stratum corneum. Here, we report a conformable ultrasound patch (cUSP) that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis in the fluid coupling medium between the patch and the skin. The cUSP consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets (0.8 cm², 1 mm deep) over larger areas of conformal contact (20 cm²). Multiphysics simulation models, acoustic spectrum analysis and high-speed videography are used to characterize transducer deflection, acoustic pressure fields and resulting cavitation bubble dynamics in the coupling medium. The final system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro with a 10-minute ultrasound application, demonstrating suitability of the device for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.</Abstract>
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