2026-09-18T19:51:40Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/1591222025-07-04T04:50:56Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Jacobson, Joseph M.
Boyden, Edward S.
Zhang, Ruihan
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
2025-04-14T14:06:55Z
2025-04-14T14:06:55Z
2025-02
2025-03-14T18:22:33.203Z
https://hdl.handle.net/1721.1/159122
0000-0002-1564-5907
This study utilizes Expansion Sequencing (ExSeq) to thoroughly investigate the spatial transcriptome of the Caenorhabditis elegans (C. elegans) body. Beyond mapping gene distribution within individual specimens, this research sequences multiple C. elegans to identify both shared and distinct transcriptomic features. The findings lay crucial groundwork for future integration of transcriptomic data with in situ connectomics and in vivo neural activity recordings. Understanding the spatial transcriptome in C. elegans is vital for insights into neural circuit coordination, disease mechanisms, and developmental biology.
Ph.D.
Massachusetts Institute of Technology
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https://rightsstatements.org/page/InC-EDU/1.0/
Mapping the Spatial Transcriptome Across Whole Organisms
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Doctoral
Doctor of Philosophy
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<Abstract>This study utilizes Expansion Sequencing (ExSeq) to thoroughly investigate the spatial transcriptome of the Caenorhabditis elegans (C. elegans) body. Beyond mapping gene distribution within individual specimens, this research sequences multiple C. elegans to identify both shared and distinct transcriptomic features. The findings lay crucial groundwork for future integration of transcriptomic data with in situ connectomics and in vivo neural activity recordings. Understanding the spatial transcriptome in C. elegans is vital for insights into neural circuit coordination, disease mechanisms, and developmental biology.</Abstract>
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