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oai:dspace.mit.edu:1721.1/1629682025-10-07T04:14:47Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023

Davis, Randall Xu, Jessica J. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science 2025-10-06T17:37:23Z 2025-10-06T17:37:23Z 2025-05 2025-06-23T14:04:30.751Z https://hdl.handle.net/1721.1/162968 Neurodegenerative diseases, such as Alzheimer’s, impact many people worldwide and currently have no cure, making early detection essential for effective symptom management and intervention. Traditional diagnostic practices often rely on subjective clinical evaluations that can vary between practitioners, highlighting the need for more objective methods. The digital Symbol Digit Test (dSDT), administered via the Cognitive Health App on an iPad and using the ETVision Eye Tracking System, aims to provide an automated, reliable method to analyze patient cognitive function to detect early signs of impairment through capturing handwriting and gaze data. This thesis builds upon previous work by automating the synchronization of these two data modalities, refining definitions of learning behaviors, and developing pipelines for data processing and visualization. By creating a synchronized multimodal dataset, we can visualize participant behavior for more intuitive interpretation and draw meaningful conclusions. These contributions provide an end-to-end framework for analyzing behavior during the cognitive assessment and lay the groundwork for future development of diagnostic models to detect early signs of neurodegenerative diseases. M.Eng. Massachusetts Institute of Technology In Copyright - Educational Use Permitted Copyright retained by author(s) https://rightsstatements.org/page/InC-EDU/1.0/ Digital Symbol Digit Test: Multimodal Behavior Detection and Visualization Thesis application/pdf Master Master of Engineering in Electrical Engineering and Computer Science Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="35fa897b-f889-4a29-8a0f-16efb4710436"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Title>Digital Symbol Digit Test: Multimodal Behavior Detection and Visualization</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2025-05</PublicationDate> <Authors> <Author> <DisplayName>Xu, Jessica J.</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://rightsstatements.org/page/InC-EDU/1.0/</License> <Abstract>Neurodegenerative diseases, such as Alzheimer’s, impact many people worldwide and currently have no cure, making early detection essential for effective symptom management and intervention. Traditional diagnostic practices often rely on subjective clinical evaluations that can vary between practitioners, highlighting the need for more objective methods. The digital Symbol Digit Test (dSDT), administered via the Cognitive Health App on an iPad and using the ETVision Eye Tracking System, aims to provide an automated, reliable method to analyze patient cognitive function to detect early signs of impairment through capturing handwriting and gaze data. This thesis builds upon previous work by automating the synchronization of these two data modalities, refining definitions of learning behaviors, and developing pipelines for data processing and visualization. By creating a synchronized multimodal dataset, we can visualize participant behavior for more intuitive interpretation and draw meaningful conclusions. These contributions provide an end-to-end framework for analyzing behavior during the cognitive assessment and lay the groundwork for future development of diagnostic models to detect early signs of neurodegenerative diseases.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>