2026-09-18T19:52:20Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/286742022-01-13T07:54:15Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Richard A. Young.
Rinaldi, Nicola J., 1974-
Massachusetts Institute of Technology. Dept. of Biology.
Massachusetts Institute of Technology. Department of Biology
2005-09-27T17:39:37Z
2005-09-27T17:39:37Z
2004
2004
http://hdl.handle.net/1721.1/28674
58994970
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.
Includes bibliographical references.
The research in this thesis has focused on the analysis of data from two types of microarray technologies with the goal of improving understanding of transcriptional regulatory circuitry in yeast. These microarray technologies, expression analysis and location analysis (ChIP on CHIP), bring unique challenges for data analysis. I have adapted methods described previously and have developing new algorithms for addressing some of these challenges. I generated yeast transcription factor location data as part of a team effort to determine how a large set of transcriptional regulators occupy the yeast genome and to facilitate discovery of regulatory network structures. I also contributed to another team effort to deduce a portion of the yeast transcriptional regulatory code, the set of genomic DNA sequences recognized by transcriptional regulators to effect gene expression programs. Finally, I used these experimental and analytical methods to explore changes in gene expression circuitry that occur after exposure to oxidative stress in yeast.
by Nicola J. Rinaldi.
Ph.D.
195 leaves
10067993 bytes
10092615 bytes
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Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Biology.
Analysis of transcriptional regulatory circuitry
Thesis
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Publication
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unknown
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