2026-09-18T20:10:18Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/286752022-01-13T07:54:15Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Frank B. Gertler.
Menzies, Annabelle Sheila, 1972-
Massachusetts Institute of Technology. Dept. of Biology.
Massachusetts Institute of Technology. Department of Biology
2005-09-27T17:40:00Z
2005-09-27T17:40:00Z
2004
2004
http://hdl.handle.net/1721.1/28675
58995025
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.
Includes bibliographical references.
Nervous system development is a complex morphogenetic process. Cell migration, axon guidance and many other regulated cell shape changes build a functional nervous system. These processes depend upon regulation of the actin cytoskeleton. Ena/VASP proteins are able to remodel the actin cytoskeleton in response to extracellular signals and have been shown to regulate the motility and morphology of a variety of cells. I have investigated the in vivo requirement for the vertebrate family members, Mena and VASP in nervous system development. I show that Mena and VASP are required for viability and the formation of the neural tube, spinal nerves and several brain commissures. Furthermore, I have investigated Ena/VASP function in neuronal cell migration using an in vitro assay and demonstrate that Ena/VASP proteins regulate the migration of cerebellar granule cells.
by Annabelle Sheila Menzies.
Ph.D.
207 leaves
11545575 bytes
11572292 bytes
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Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Biology.
Ena/VASP proteins regulate vertebrate nervous system development : a thesis presented
Thesis
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<Abstract>Nervous system development is a complex morphogenetic process. Cell migration, axon guidance and many other regulated cell shape changes build a functional nervous system. These processes depend upon regulation of the actin cytoskeleton. Ena/VASP proteins are able to remodel the actin cytoskeleton in response to extracellular signals and have been shown to regulate the motility and morphology of a variety of cells. I have investigated the in vivo requirement for the vertebrate family members, Mena and VASP in nervous system development. I show that Mena and VASP are required for viability and the formation of the neural tube, spinal nerves and several brain commissures. Furthermore, I have investigated Ena/VASP function in neuronal cell migration using an in vitro assay and demonstrate that Ena/VASP proteins regulate the migration of cerebellar granule cells.</Abstract>
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