2026-09-19T10:31:46Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/287072022-01-13T07:54:21Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Bernhardt L. Trout.
Chang, Nai-yuan, 1973-
Massachusetts Institute of Technology. Dept. of Chemistry.
Massachusetts Institute of Technology. Department of Chemistry
2005-09-27T17:53:49Z
2005-09-27T17:53:49Z
2004
2004
http://hdl.handle.net/1721.1/28707
59133389
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.
Includes bibliographical references (leaf 26).
In this study, thermodynamic integration and molecular dynamics methods were used to elucidate the factors affecting stabilities of collagen-like peptides. We proposed to investigate three specific aspects: (1) the stabilizing effect of hydroxyproline (Hyp), (2) the destabilizing effect of replacing Gly, and (3) the role of water mediated hydrogen bonds. A better understanding of the origins of the stabilities of collagens will help in the design of new biomaterials and the treatment of collagen-related diseases.
by Nai-yuan Chang.
S.M.
26 leaves
1058316 bytes
1058598 bytes
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Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Chemistry.
Computational studies on the factors influencing stabilities of collagen-like peptides
Thesis
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