2026-09-19T21:14:34Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/288672022-01-13T07:54:15Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Jacqueline A. Lees.
Eipper-Mains, Marcie A., 1979-
Massachusetts Institute of Technology. Dept. of Biology.
Massachusetts Institute of Technology. Department of Biology
2005-09-27T18:46:43Z
2005-09-27T18:46:43Z
2004
2004
http://hdl.handle.net/1721.1/28867
60412771
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.
Includes bibliographical references (leaves [54]-[66]).
The development of the immune system is a highly dynamic process, characterized by quickly and frequently changing cell types and numbers. The orchestration of cell growth and proliferation and also of cell death is a necessarily complex process, taking cues from a wide variety of sources. The nematode Caenorhabditus elegans has provided an elegant and simple model of the control of programmed cell death, or apoptosis, in metazoans. Apoptosis in mammals is regulated by pathways related to but more intricate than metazoans. Several key features define the onset of apoptosis in any given cell; these include DNA fragmentation and chromatin condensation, "blebbing" of the plasma membrane, and subsequent phagocytosis of the resulting cell fragments by adjacent cells (Kerr et al. 1972 and Wyllie et al. 1980).
by Marcie A. Eipper-Mains.
S.M.
50, [16] leaves
4023616 bytes
4030350 bytes
application/pdf
application/pdf
en_US
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Biology.
The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases
Thesis
application/pdf
false
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="f7339e17-6f38-4f20-b947-64f3a3a832e1">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>en_US</Language>
<Title>The role of the Bcl-2 family in proliferation and apoptosis and in mediating the development of lymphatic diseases</Title>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2004</PublicationDate>
<Authors>
<Author>
<DisplayName>Eipper-Mains, Marcie A., 1979-</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Biology.</Keyword>
<Abstract>The development of the immune system is a highly dynamic process, characterized by quickly and frequently changing cell types and numbers. The orchestration of cell growth and proliferation and also of cell death is a necessarily complex process, taking cues from a wide variety of sources. The nematode Caenorhabditus elegans has provided an elegant and simple model of the control of programmed cell death, or apoptosis, in metazoans. Apoptosis in mammals is regulated by pathways related to but more intricate than metazoans. Several key features define the onset of apoptosis in any given cell; these include DNA fragmentation and chromatin condensation, "blebbing" of the plasma membrane, and subsequent phagocytosis of the resulting cell fragments by adjacent cells (Kerr et al. 1972 and Wyllie et al. 1980).</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>