2026-09-18T19:46:49Zhttps://dspace.mit.edu/server/oai/request

oai:dspace.mit.edu:1721.1/288712022-01-13T07:54:33Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023

Christine Ortiz. Domike, Kristin Rebecca, 1981- Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Department of Materials Science and Engineering 2005-09-27T18:47:58Z 2005-09-27T18:47:58Z 2004 2004 http://hdl.handle.net/1721.1/28871 60425230 Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2004. Includes bibliographical references. Endotracheal tubes (ETs) are used to aid artificial ventilation in millions of medical patients every year and are known to invoke the proliferative phase in the cell linings. The technical objective of this work was to investigate in vitro the interaction between epithelial cells and current poly(vinyl chloride)-based ET materials, as well as some ET samples embedded with materials intended to improve biocompatibility properties of the tubes. Cells were grown in wells with small samples of ETs and proliferation and migration were observed using phase microscopy. ETs appeared to increase cell growth wherever cells came into contact with the material. The cell morphology altered once in contact with the ET sample. Cell growth on and around the ETs with embedded material appeared to slow, but had significant visible changes in cell morphology. The need for continued research in this area of research and development and future steps are addressed. A proposal for starting a company around a safer material for use in endotracheal tubes was developed and showed significant barriers to entry for a small medical device company with a single product. Subsequently, the most appropriate approach for bringing a new ET to the market would be by way of a licensing with an existing manufacturer. by Kristin Rebecca Domike. M.Eng. 71 leaves 4987553 bytes 4994618 bytes application/pdf application/pdf en_US Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Materials Science and Engineering. The impact of improved materials in poly(vinyl chloride)-based endotracheal tubes Thesis application/pdf Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="22d1de6f-627b-4478-b373-65c5fc1a04ae"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>en_US</Language> <Title>The impact of improved materials in poly(vinyl chloride)-based endotracheal tubes</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2004</PublicationDate> <Authors> <Author> <DisplayName>Domike, Kristin Rebecca, 1981-</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Materials Science and Engineering.</Keyword> <Abstract>Endotracheal tubes (ETs) are used to aid artificial ventilation in millions of medical patients every year and are known to invoke the proliferative phase in the cell linings. The technical objective of this work was to investigate in vitro the interaction between epithelial cells and current poly(vinyl chloride)-based ET materials, as well as some ET samples embedded with materials intended to improve biocompatibility properties of the tubes. Cells were grown in wells with small samples of ETs and proliferation and migration were observed using phase microscopy. ETs appeared to increase cell growth wherever cells came into contact with the material. The cell morphology altered once in contact with the ET sample. Cell growth on and around the ETs with embedded material appeared to slow, but had significant visible changes in cell morphology. The need for continued research in this area of research and development and future steps are addressed. A proposal for starting a company around a safer material for use in endotracheal tubes was developed and showed significant barriers to entry for a small medical device company with a single product. Subsequently, the most appropriate approach for bringing a new ET to the market would be by way of a licensing with an existing manufacturer.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>