2026-09-20T21:20:30Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/324902022-01-13T07:54:21Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Stephen L. Buchwald.
Hirai, Satoko
Massachusetts Institute of Technology. Dept. of Chemistry.
Massachusetts Institute of Technology. Department of Chemistry
2006-03-29T18:49:22Z
2006-03-29T18:49:22Z
2005
2005
http://hdl.handle.net/1721.1/32490
61858035
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.
Includes bibliographical references.
The asymmetric biaryl backbone of a dialkylbiphenyl phosphine ligand was developed, synthesized, and resolved. The application of the chiral phosphine ligand to the asymmetric Suzuki-Miyaura cross-coupling reaction was also investigated. This phosphine ligand has yielded promising results in the asymmetric Suzuki-coupling of hindered boronic acids with the electron-rich aryl bromide, 1-bromo-2- methoxynaphthalene, to synthesize biaryls in modest enantioselectivity.
by Satoko Hirai.
S.M.
64 p.
2246142 bytes
2247943 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Chemistry.
The synthesis and applications of a biaryl-based asymmetric phosphine ligand
Thesis
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