2026-09-19T12:12:39Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/328122022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Klavs F. Jensen.
Griswold, Aaron A. (Aaron Alexander), 1981-
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2006-05-15T20:31:56Z
2006-05-15T20:31:56Z
2004
2004
http://hdl.handle.net/1721.1/32812
57588533
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.
Includes bibliographical references (leaf 18).
A miniaturized bioreactor with a volume on the order of 100 [micro]l has been built with the aim of increasing the efficiency of the screening process for various microbial cultures. Unlike larger reactors currently in use, the current miniaturized design lacks a method of pH control. Without pH control, cell growth can be hindered or even stopped altogether when the growing medium becomes too acidic. Using technology already in place to optically measure the pH inside the reactor in conjunction with a valve and a base-filled reservoir, a simple closed-loop (feedback) control system has been developed. The volume of base injected into the reactor must be minimized because the reactor itself is so small. Data is recorded and control signals are outputted by a computer running LabView software. While the control system developed in this thesis shows promise, further development is needed before it can be put to good use.
by Aaron A. Griswold.
S.B.
18 leaves
944171 bytes
941817 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
pH control in a miniaturized bioreactor
Hydrogen-ion concentration control in a miniaturized bioreactor
Thesis
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