2026-09-23T15:12:14Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/328222022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Ian W. Hunter.
Del Zio, Michael R. (Michael Robert), 1982-
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2006-05-15T20:32:38Z
2006-05-15T20:32:38Z
2004
2004
http://hdl.handle.net/1721.1/32822
57615152
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.
Includes bibliographical references (leaves 42-43).
A process known as mutational spectrometry allows the detection of both single and multiple mutations that appear to be spontaneous, using a technique known as constant denaturing capillary electrophoresis (CDCE). CDCE requires a region of constant temperature and concentration of denaturant. A massively parallel, fully automated instrument, capable of handling as many as 10,000 DNA samples simultaneously, is suited to this technique. A modular structure of such a mutational spectrometer was designed to remain water-tight, provide an array to hold the capillaries for electrophoretic excitation, and modulate the flow of a heat transfer fluid. Six such modules were manufactured and assembled. As the heat transfer fluid passed through the assembled structure, the natural thermal loss was determined.
by Michael R. Del Zio.
S.B.
43 leaves
4423487 bytes
4423616 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Design and testing of the thermal properties of the structure of an ultra high-throughput mutational spectrometer
Thesis
application/pdf
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unknown
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