2026-09-19T02:40:01Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/329162022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Todd Thorsen.
Smith, Emily (Emily C.)
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2006-05-15T20:39:04Z
2006-05-15T20:39:04Z
2005
2005
http://hdl.handle.net/1721.1/32916
62763523
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
Includes bibliographical references (leaves 45-46).
Microfluidics has the ability to greatly reduce the time needed to do many biological tests. The development of polymers has brought about substrates with elastomeric properties that can be used to the advantage of microfluidic device design. Elastomeric polymers can be used to create small scale passive valve systems. These valves can compartmentalize reactions in devices. Current microreactors only allow researchers to do one test at a time. Devices with the capability to compartmentalize reactions using valves could perform multiple reactions simultaneously. This thesis details the fabrication and design of a microreactor that can maintain cells in the device after a reaction. The fabrication of the device was done without a clean room and using no specialized equipment. Creation of the device and using it for testing requires little training and takes less time than performing the test using conventional methods. The device could readily be made and used by researchers using equipment already in their lab and is cheaper than current devices on the market.
by Emily Smith.
S.B.
46 leaves
1937593 bytes
1937863 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Fabrication of a picoliter microreactor with multilayer elastomer values
Thesis
application/pdf
Publication
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unknown
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<Abstract>Microfluidics has the ability to greatly reduce the time needed to do many biological tests. The development of polymers has brought about substrates with elastomeric properties that can be used to the advantage of microfluidic device design. Elastomeric polymers can be used to create small scale passive valve systems. These valves can compartmentalize reactions in devices. Current microreactors only allow researchers to do one test at a time. Devices with the capability to compartmentalize reactions using valves could perform multiple reactions simultaneously. This thesis details the fabrication and design of a microreactor that can maintain cells in the device after a reaction. The fabrication of the device was done without a clean room and using no specialized equipment. Creation of the device and using it for testing requires little training and takes less time than performing the test using conventional methods. The device could readily be made and used by researchers using equipment already in their lab and is cheaper than current devices on the market.</Abstract>
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