2026-09-19T16:20:05Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/329322022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Ian W. Hunter.
Sanchez, Gabriel Nestor
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2006-05-15T20:40:09Z
2006-05-15T20:40:09Z
2004
2005
http://hdl.handle.net/1721.1/32932
62776203
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2005.
Includes bibliographical references (leaf 33).
The purpose of this thesis was to develop an optimized nozzle for the needle-free injection device currently under construction in MIT's Bio-Instrumentation Laboratory. Initial predictions from ANSYS, a finite element modeling program, indicated that the injection performance could be noticeably improved with a new nozzle design. After running several flow simulations, a final nozzle design was selected, and a strategy was developed to manufacture the new nozzle. The new nozzle was placed in the injection device and measurements of the jet velocity were recorded via a high speed camera. A 2mm long nozzle with a contoured profile consisting of a linear segment tangent to an arc segment at the nozzle exit produced an exit velocity of 45.5m/s at the end of the injection stroke. This showed almost a 19 percent increase in velocity compared to the older nozzle which produced 38. lm/s upon termination of the injection cycle. However, the results of the new nozzle vary from injection to injection. Thus there is a need for continued testing in the future, and possibly more refined measuring techniques such as depth of penetration into the gel or developing improvements with the current video setup.
by Gabriel Nestor Sanchez.
S.B.
34 leaves
1803352 bytes
1802464 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Design and optimization of a nozzle for a needle-free injection system
Nozzle for a needle-free injection system
Thesis
application/pdf
false
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="f008b563-5f02-4581-90b4-e0331fe3cbab">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Design and optimization of a nozzle for a needle-free injection system</Title>
<Subtitle>Nozzle for a needle-free injection system</Subtitle>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2005</PublicationDate>
<Authors>
<Author>
<DisplayName>Sanchez, Gabriel Nestor</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Mechanical Engineering.</Keyword>
<Abstract>The purpose of this thesis was to develop an optimized nozzle for the needle-free injection device currently under construction in MIT's Bio-Instrumentation Laboratory. Initial predictions from ANSYS, a finite element modeling program, indicated that the injection performance could be noticeably improved with a new nozzle design. After running several flow simulations, a final nozzle design was selected, and a strategy was developed to manufacture the new nozzle. The new nozzle was placed in the injection device and measurements of the jet velocity were recorded via a high speed camera. A 2mm long nozzle with a contoured profile consisting of a linear segment tangent to an arc segment at the nozzle exit produced an exit velocity of 45.5m/s at the end of the injection stroke. This showed almost a 19 percent increase in velocity compared to the older nozzle which produced 38. lm/s upon termination of the injection cycle. However, the results of the new nozzle vary from injection to injection. Thus there is a need for continued testing in the future, and possibly more refined measuring techniques such as depth of penetration into the gel or developing improvements with the current video setup.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>