2026-09-21T19:16:42Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/344842026-06-10T16:45:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Guosong Liu.
Krupa, Boris
Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences.
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
2008-02-28T16:24:13Z
2008-02-28T16:24:13Z
2006
2006
http://hdl.handle.net/1721.1/34484
70785940
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2006.
Includes bibliographical references.
Introduction: This thesis contains two main projects that I worked on during my graduate studies at MIT. Both address the subject matter of how neurons communicate, process, and pass information within the context of larger neuronal ensembles. The first project focuses on information transfer between two neurons during synaptic transmission. The project was spurred by an initial observation that neuronal communication through synapses in young and developing neuronal networks is only "half-hearted" in that signals propagate predominantly through only one type of synaptic receptor (the NMDA receptor), and bypass the principal signaling pathway present in mature synaptic transmission (AMPA receptor) (Malenka and Nicoll 1997). The possible cause of this abnormality was either that AMPA receptors were lacking on the postsynaptic side, or that something else in the process of synaptic transmission rendered them inoperable.
by Boris Krupa.
Ph.D.
[77] p. in various pagings
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Brain and Cognitive Sciences.
Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission
Effects of the release time course of neurotransmitter on synaptic transmission
Thesis
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<Abstract>Introduction: This thesis contains two main projects that I worked on during my graduate studies at MIT. Both address the subject matter of how neurons communicate, process, and pass information within the context of larger neuronal ensembles. The first project focuses on information transfer between two neurons during synaptic transmission. The project was spurred by an initial observation that neuronal communication through synapses in young and developing neuronal networks is only "half-hearted" in that signals propagate predominantly through only one type of synaptic receptor (the NMDA receptor), and bypass the principal signaling pathway present in mature synaptic transmission (AMPA receptor) (Malenka and Nicoll 1997). The possible cause of this abnormality was either that AMPA receptors were lacking on the postsynaptic side, or that something else in the process of synaptic transmission rendered them inoperable.</Abstract>
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