2026-09-19T08:24:16Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/351372022-01-13T07:54:33Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Michael J. Cima.
Kim, Jina, 1984-
Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.
Massachusetts Institute of Technology. Department of Materials Science and Engineering
2006-12-18T20:46:20Z
2006-12-18T20:46:20Z
2006
2006
http://hdl.handle.net/1721.1/35137
71844557
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.
Includes bibliographical references (leaf 22).
This work builds on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs that are fabricated via lamination, and a final design was proposed based on the results. Design 1 sought to replace the sealant directly with a PLA backing layer, but the laminated backing layer was found to leak in 14C-dextran release experiments. Design 2 used a laminated film instead of the original injected membrane. The laminated film was optimized to a 200- [mu]m thick poly(D,L-lactic-co-glycolic acid) 2A membrane, and the film-laminated microchip was shown to release 14C-dextran within a 40-day period. The final proposed design was based on Design 2, which demonstrated more potential as a future means of drug delivery.
by Jina Kim.
S.B.
22 leaves
1010076 bytes
1008079 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Materials Science and Engineering.
Lamination of a biodegradable polymeric microchip
Thesis
application/pdf
Publication
unknown
unknown
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