2026-09-21T01:04:10Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/353092022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Ian W. Hunter.
Wendell, Dawn M. (Dawn Marie), 1983-
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2007-01-10T15:38:28Z
2007-01-10T15:38:28Z
2006
http://hdl.handle.net/1721.1/35309
76759875
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2006.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
"May 2006."
Includes bibliographical references (leaves 32-33).
Current needle-free injection technology is based on actuation via compressed springs or gas. These devices are not easy to modify for different depths of injections. This thesis describes the design and verification of a handheld needle-free device which is capable of various injection depths via electrical control of a Lorentz-force voice coil actuator. A benchtop proof-of-concept device was created to prove the concept of needle-free injection using a voice coil. After the successful testing of the proof-of-concept device, a handheld prototype was designed, manufactured, and tested. The controllability of injections was tested on excised sheep tissue in-vitro. The handheld device was also tested in-vivo on sheep midside and was shown to give comparable injections to a needle for delivery of the drug collagenase. The controllable needle-free injection principles described in this thesis could be used in human or veterinary applications.
by Dawn M. Wendell.
S.M.
45 leaves
3202973 bytes
3202557 bytes
application/pdf
application/pdf
eng
Massachusetts Institute of Technology
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http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Controllable needle-free injection : development and verification of a novel device
Thesis
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<Abstract>Current needle-free injection technology is based on actuation via compressed springs or gas. These devices are not easy to modify for different depths of injections. This thesis describes the design and verification of a handheld needle-free device which is capable of various injection depths via electrical control of a Lorentz-force voice coil actuator. A benchtop proof-of-concept device was created to prove the concept of needle-free injection using a voice coil. After the successful testing of the proof-of-concept device, a handheld prototype was designed, manufactured, and tested. The controllability of injections was tested on excised sheep tissue in-vitro. The handheld device was also tested in-vivo on sheep midside and was shown to give comparable injections to a needle for delivery of the drug collagenase. The controllable needle-free injection principles described in this thesis could be used in human or veterinary applications.</Abstract>
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