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Subra Suresh and Simona Socrate. Prévost, Thibault Philippe Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Department of Materials Science and Engineering 2007-02-21T13:08:35Z 2007-02-21T13:08:35Z 2006 2006 http://hdl.handle.net/1721.1/36217 76906810 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006. Includes bibliographical references (leaves 108-115). The human fetal membrane, namely the chorioamnion, is the structural soft tissue retaining the amniotic fluid and the fetus during pregnancy. Its biomechanical integrity is crucial for maintaining a healthy gestation and a successful delivery. The premature rupture of the fetal membrane (PROM) can result in serious perinatal complications. Despite extensive research in this field, the mechanical and biochemical processes governing the membrane deformation and failure remain poorly understood. The aim of this study is to characterize the mechanical behavior of the chorioamnionic tissue along with its biochemical properties, through mechanical testing and biochemical analyses. In order to accomplish this goal, specific mechanical and biochemical testing protocols were developed. In vitro mechanical testing was performed on samples from seven patients under different uniaxial and biaxial loading conditions. Significant relaxation was noted under uniaxial loading while very limited creep was observed under biaxial loading. Biochemical measurements such as collagen and sulfated glycosaminoglycan contents were also obtained. In addition, a microstructurally based constitutive model for the fetal membrane is proposed. (cont.) The model allows for nonlinear hyperelastic response at large deformation. We also propose a framework to capture the time-dependent response of the tissue. The model was implemented in a finite element formulation to allow three-dimensional simulations of membrane deformation. by Thibault Philippe Prévost. S.M. 115 leaves eng Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Materials Science and Engineering. Biomechanics of the human chorioamnion Thesis application/pdf false Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="86391051-35ab-4590-9256-b14f108a5b18"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Biomechanics of the human chorioamnion</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2006</PublicationDate> <Authors> <Author> <DisplayName>Prévost, Thibault Philippe</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Materials Science and Engineering.</Keyword> <Abstract>The human fetal membrane, namely the chorioamnion, is the structural soft tissue retaining the amniotic fluid and the fetus during pregnancy. Its biomechanical integrity is crucial for maintaining a healthy gestation and a successful delivery. The premature rupture of the fetal membrane (PROM) can result in serious perinatal complications. Despite extensive research in this field, the mechanical and biochemical processes governing the membrane deformation and failure remain poorly understood. The aim of this study is to characterize the mechanical behavior of the chorioamnionic tissue along with its biochemical properties, through mechanical testing and biochemical analyses. In order to accomplish this goal, specific mechanical and biochemical testing protocols were developed. In vitro mechanical testing was performed on samples from seven patients under different uniaxial and biaxial loading conditions. Significant relaxation was noted under uniaxial loading while very limited creep was observed under biaxial loading. Biochemical measurements such as collagen and sulfated glycosaminoglycan contents were also obtained. In addition, a microstructurally based constitutive model for the fetal membrane is proposed.</Abstract> <Abstract>(cont.) The model allows for nonlinear hyperelastic response at large deformation. We also propose a framework to capture the time-dependent response of the tissue. The model was implemented in a finite element formulation to allow three-dimensional simulations of membrane deformation.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>