2026-09-18T19:46:42Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/366832022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Lorna Gibson.
Wong, Matthew Q
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2007-03-12T17:44:04Z
2007-03-12T17:44:04Z
2006
2006
http://hdl.handle.net/1721.1/36683
77536944
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.
Includes bibliographical references (p. 43-45).
An experimental study was performed to determine whether or not collagen-GAG scaffolds exhibit linear viscoelastic behavior. Tension tests were performed on dry and hydrated engineered collagen-GAG scaffolds in order to develop a stress-strain curve. Strains that fell in the linear elastic region of these curves were selected and then used in stress relaxation tests that were also performed on dry and hydrated specimens. The relaxation modulus was calculated from the resulting stress relaxation curves at different strain levels and compared to each other to determine viscoelastic linearity. In addition to the determination of viscoelastic linearity, a water bath was designed in the hopes of performing stress relaxation tests in hydrated environment with the temperature maintained at 37°C, the temperature of the human body. These tests will aid in the future studies of how cells contract and apply force to the scaffolds since no previous studies have looked at the time dependent mechanical properties of these scaffolds. Moreover, the data can be used in the future to determine whether the viscoelastic response contributes to cellular processes such as migration speeds, attachment, and contraction.
by Matthew Q. Wong.
S.B.
45 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Viscoelastic characterization of collagen-GAG scaffolds
Thesis
application/pdf
Publication
unknown
unknown
<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="7662d858-754d-4f3a-b00d-861fd5807a22">
<Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type>
<Language>eng</Language>
<Title>Viscoelastic characterization of collagen-GAG scaffolds</Title>
<PublishedIn>
<Publication>
</Publication>
</PublishedIn>
<PublicationDate>2006</PublicationDate>
<Authors>
<Author>
<DisplayName>Wong, Matthew Q</DisplayName>
<Affiliation>
<OrgUnit>
</OrgUnit>
</Affiliation>
</Author>
</Authors>
<Editors>
</Editors>
<Publishers>
<Publisher>
<DisplayName>Massachusetts Institute of Technology</DisplayName>
<OrgUnit />
</Publisher>
</Publishers>
<License>http://dspace.mit.edu/handle/1721.1/7582</License>
<Keyword>Mechanical Engineering.</Keyword>
<Abstract>An experimental study was performed to determine whether or not collagen-GAG scaffolds exhibit linear viscoelastic behavior. Tension tests were performed on dry and hydrated engineered collagen-GAG scaffolds in order to develop a stress-strain curve. Strains that fell in the linear elastic region of these curves were selected and then used in stress relaxation tests that were also performed on dry and hydrated specimens. The relaxation modulus was calculated from the resulting stress relaxation curves at different strain levels and compared to each other to determine viscoelastic linearity. In addition to the determination of viscoelastic linearity, a water bath was designed in the hopes of performing stress relaxation tests in hydrated environment with the temperature maintained at 37°C, the temperature of the human body. These tests will aid in the future studies of how cells contract and apply force to the scaffolds since no previous studies have looked at the time dependent mechanical properties of these scaffolds. Moreover, the data can be used in the future to determine whether the viscoelastic response contributes to cellular processes such as migration speeds, attachment, and contraction.</Abstract>
<Access xmlns="http://purl.org/coar/access_right"
>
</Access>
</Publication>