2026-09-19T12:13:36Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/372582022-01-13T07:54:15Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Drew Endy.
Gritton, Jeffrey S
Massachusetts Institute of Technology. Dept. of Biology.
Massachusetts Institute of Technology. Department of Biology
2007-04-20T15:57:39Z
2007-04-20T15:57:39Z
2006
http://hdl.handle.net/1721.1/37258
85844464
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.
"September 2006."
Includes bibliographical references (leaves 37-38).
I have researched the effect that selection for the function of the High Osmolarity Glycerol (HOG) pathway has on the evolutionary stability of the pheromone response pathway in the yeast Saccharomyces cerevisiae. I first set out to demonstrate that, because the pheromone and HOG response pathways share protein components, selection for HOG function will enrich a population for cells capable of pheromone response. I performed experiments in both continuous and batch culture to demonstrate this effect. I then characterized the decay of the pheromone response pathway first, by measuring its mutation rate and second, by measuring the fitness of a series of strains with pheromone response gene deletions. I conclude with thoughts on possible experiments that may be used to further this research.
by Jeffrey S. Gritton.
S.M.
45 leaves
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Biology.
Architecture and evolutionary stability of yeast signaling pathways
Thesis
application/pdf
Publication
unknown
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