2026-09-20T16:57:57Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/389892022-01-13T07:54:15Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Rudolph Jaenisch.
Nguyen, Suzanne Pham
Massachusetts Institute of Technology. Dept. of Biology.
Massachusetts Institute of Technology. Department of Biology
2007-09-28T13:27:57Z
2007-09-28T13:27:57Z
2007
2007
http://hdl.handle.net/1721.1/38989
166409256
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.
Includes bibliographical references.
DNA methylation is an important mechanism of gene regulation. Evidence is mounting that epigenetic mechanisms including that of DNA methylation operate in the nervous system. Genetic disruption of the de novo DNA methyltransferase Dnmt3a in mice were used to elucidate the role of the enzyme in the nervous system. Inactivating Dnmt3a in the nervous system resulted in a drastically shortened lifespan and in behavioral abnormalities that suggested a motor defect. Dnmt3a mutants also exhibited motor neuron loss and fragmented neuromuscular junction synapses. These results support a requirement for DNA methyltransferase activity in the neuromuscular system.
by Suzanne Pham Nguyen.
Ph.D.
187 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Biology.
The role of the de novo DNA methyltransferase Dnmt3a in the nervous system
Thesis
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