2026-09-21T00:16:18Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/415962022-01-13T07:54:37Zcom_1721.1_7582com_1721.1_7581col_1721.1_131024
Jeffrey Coderre.
Sheppard, Sarah (Sarah Elizabeth)
Massachusetts Institute of Technology. Dept. of Nuclear Science and Engineering.
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
2008-05-19T15:58:37Z
2008-05-19T15:58:37Z
2006
http://hdl.handle.net/1721.1/41596
213498151
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2006.
"June 2006."
Includes bibliographical references (p. 30-32).
The bystander effect is seen when irradiated cells release a factor that can produce damage or death in neighboring "bystander" cells that are not actually hit by any radiation. One proposed mechanism involves the irradiated cells releasing a soluble factor into the medium that can cause damage to the non-irradiated cells. Previous studies in the Coderre lab showed that the soluble factor released by DU-145 human prostate carcinoma cells was a short-lived, free radical species (Wang and Coderre, Rad. Res., 164, 711-722, 2005). This thesis examined the effect of temperature on the bystander effect. A co-culture system was used to create irradiated and bystander DU-145 cells in the same medium. This thesis showed that a decrease in temperature lessens or prevents the bystander effect. Researching the bystander effect will allow a better understanding of a process that may already be occurring during alpha-particle based therapies such as boron neutron capture therapy (BNCT) and tumor radioimmunotherapy and could provide a means to improve these therapies.
by Sarah Sheppard.
S.B.
32 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
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http://dspace.mit.edu/handle/1721.1/7582
Nuclear Science and Engineering.
The effect of temperature on the bystander effect as examined in human prostate carcinoma cells with alpha particle irradiation
Thesis
application/pdf
Publication
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<Abstract>The bystander effect is seen when irradiated cells release a factor that can produce damage or death in neighboring "bystander" cells that are not actually hit by any radiation. One proposed mechanism involves the irradiated cells releasing a soluble factor into the medium that can cause damage to the non-irradiated cells. Previous studies in the Coderre lab showed that the soluble factor released by DU-145 human prostate carcinoma cells was a short-lived, free radical species (Wang and Coderre, Rad. Res., 164, 711-722, 2005). This thesis examined the effect of temperature on the bystander effect. A co-culture system was used to create irradiated and bystander DU-145 cells in the same medium. This thesis showed that a decrease in temperature lessens or prevents the bystander effect. Researching the bystander effect will allow a better understanding of a process that may already be occurring during alpha-particle based therapies such as boron neutron capture therapy (BNCT) and tumor radioimmunotherapy and could provide a means to improve these therapies.</Abstract>
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