2026-09-20T10:21:52Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/444232022-01-13T07:54:33Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Joseph Jacobson.
Hwang, Samuel James
Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.
Massachusetts Institute of Technology. Department of Materials Science and Engineering
2009-01-30T16:45:02Z
2009-01-30T16:45:02Z
2008
2008
http://hdl.handle.net/1721.1/44423
289478664
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2008.
Includes bibliographical references (leaves 42-43).
Deoxyribonucleic acid (DNA), the polymeric molecule that carries the genetic code of all living organisms, is arguably one of the most programmable assembly materials available to chemists, biologists, and materials scientists. Scientists have used DNA to build many different structures for various applications in disparate areas of research from traditional biological applications to more recent non-biological applications. Although DNA isn't typically thought of as an assembly material by people not doing research in the area, the availability of decreasing cost synthetic oligonucleotides has led to advances in gene fabrication technology which in turn has enabled synthetic biology to flourish. Using DNA as a building material for small and large constructs of DNA is reliant on having effective gene synthesis techniques. Construction of synthetic DNA is limited by errors that pervade the final product. To address this problem, effective error correction methods are pivotal. Having extremely robust gene synthesis and error correction techniques will allow researchers to generate very large scale constructs potentially necessary in applications such as genome re-engineering.
by Samuel James Hwang.
S.M.
43 leaves
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
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http://dspace.mit.edu/handle/1721.1/7582
Materials Science and Engineering.
DNA as a programmable material : de novo gene synthesis and error correction
Deoxyribonucleic acid as a programmable material
Thesis
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<Abstract>Deoxyribonucleic acid (DNA), the polymeric molecule that carries the genetic code of all living organisms, is arguably one of the most programmable assembly materials available to chemists, biologists, and materials scientists. Scientists have used DNA to build many different structures for various applications in disparate areas of research from traditional biological applications to more recent non-biological applications. Although DNA isn't typically thought of as an assembly material by people not doing research in the area, the availability of decreasing cost synthetic oligonucleotides has led to advances in gene fabrication technology which in turn has enabled synthetic biology to flourish. Using DNA as a building material for small and large constructs of DNA is reliant on having effective gene synthesis techniques. Construction of synthetic DNA is limited by errors that pervade the final product. To address this problem, effective error correction methods are pivotal. Having extremely robust gene synthesis and error correction techniques will allow researchers to generate very large scale constructs potentially necessary in applications such as genome re-engineering.</Abstract>
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