2026-09-18T21:13:43Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/454362022-01-13T07:54:41Zcom_1721.1_7582com_1721.1_7581col_1721.1_131022
Alexander van Oudenaarden.
O'Kelly, Michael J. T
Massachusetts Institute of Technology. Dept. of Physics.
Massachusetts Institute of Technology. Department of Physics
2009-04-29T17:41:56Z
2009-04-29T17:41:56Z
2008
2008
http://hdl.handle.net/1721.1/45436
317950968
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008.
Includes bibliographical references (p. 129-132).
A bioinformatic and laboratory investigation into S. cerevisiae's system for the maintenance and homogenization of rDNA. Eliminating mutations and heterogeneity in rDNA repeats is necessary evolutionarily, but harmful to individual organisms--and has been linked to aging-related pathology. We present a forensic investigation of this process using a new whole-genome shotgun dataset, and interpret the results in light of experimental results showing the dynamics of rDNA silencing and recombination in laboratory strains.
by Michael J.T. O'Kelly.
Ph.D.
151 p.
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
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http://dspace.mit.edu/handle/1721.1/7582
Physics.
Silencing and recombination in yeast ribosomal DNA
Thesis
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