2026-09-19T06:10:32Zhttps://dspace.mit.edu/server/oai/requestoai:dspace.mit.edu:1721.1/461622022-01-13T07:54:36Zcom_1721.1_7582com_1721.1_7581col_1721.1_131023
Stephen C. Graves.
Chen, Xiaowen, M. Eng. Massachusetts Institute of Technology
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Massachusetts Institute of Technology. Department of Mechanical Engineering
2009-06-30T17:33:34Z
2009-06-30T17:33:34Z
2008
2008
http://hdl.handle.net/1721.1/46162
399658288
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.
Includes bibliographical references (leaf 66).
An Intermediate Bulk Container (IBC) is used to contain raw materials and semi-products in pharmaceutical company ABC. Due to the high price of an IBC, company ABC sought to minimize the number of IBCs needed to support the production of four separate products. In this project, five IBCs drivers that affect or determine the number of IBCs required were identified. Deterministic models were established to determine the minimum number of IBCs needed for each product given the production plan in 2009. The cleaning schedule for IBCs was modified to reuse IBCs as much as possible. In this paper, we analyze the management of 600L IBCs. We simulate a two machines finite-buffer line model to estimate the optimum buffer size. We collected equipment downtime data to estimate the parameters for the simulation model. We use the simulation to determine the number of 600L IBCs needed for each campaign; the number of 600L IBCs was reduced from 12 to 8. Additional analysis examined the reduction of usage of 1800L IBCs.
by Xiaowen Chen.
M.Eng.
80 leaves
eng
Massachusetts Institute of Technology
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
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permission. See provided URL for inquiries about permission.
http://dspace.mit.edu/handle/1721.1/7582
Mechanical Engineering.
Optimizing the planning of IBC usage in pharmaceutical industry
Optimizing the planning of Intermediate Bulk Container usage in pharmaceutical industry
Thesis
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<Abstract>An Intermediate Bulk Container (IBC) is used to contain raw materials and semi-products in pharmaceutical company ABC. Due to the high price of an IBC, company ABC sought to minimize the number of IBCs needed to support the production of four separate products. In this project, five IBCs drivers that affect or determine the number of IBCs required were identified. Deterministic models were established to determine the minimum number of IBCs needed for each product given the production plan in 2009. The cleaning schedule for IBCs was modified to reuse IBCs as much as possible. In this paper, we analyze the management of 600L IBCs. We simulate a two machines finite-buffer line model to estimate the optimum buffer size. We collected equipment downtime data to estimate the parameters for the simulation model. We use the simulation to determine the number of 600L IBCs needed for each campaign; the number of 600L IBCs was reduced from 12 to 8. Additional analysis examined the reduction of usage of 1800L IBCs.</Abstract>
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