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Michael J. Cima. Palazzolo, Robert D. (Robert David), 1973- Massachusetts Institute of Technology. Dept. of Materials Science and Engineering. Massachusetts Institute of Technology. Department of Materials Science and Engineering 2010-01-07T21:01:42Z 2010-01-07T21:01:42Z 1998 1998 http://hdl.handle.net/1721.1/50617 47260974 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1998. Includes bibliographical references (p. 93). Pharmaceutical grade materials were used in the fabrication of fast-release and extended-release oral dosage forms. Tablets were processed by employing a method of solid freeform fabrication known as three dimensional printingTM (3DPTM). A microcrystalline cellulose powder was used in combination with pH-dependent and permeable polymeric binder solutions. Release studies in acidic media were performed using both dye and drug (antihistamine) as actives. Deposition was performed by micro pipette into concept devices. It was concluded that printing parameters could be used to control the microstructure and release behavior. The performance of a drop-on-demand inkjet printing system was evaluated to be highly accurate, and the system was used in the fabrication of model oral dosage forms. Tablets were constructed with a permeable polymer as binder. Mechanical tests showed that the tablets were comparable to industry references for both strength and friability. A USP dissolution method involving an acid and buffer stage was used for extended-release studies. Release by diffusion was found to depend on device porosity level and drug distribution as defined during fabrication. by Robert D. Palazzolo. S.M. 93 p. eng Massachusetts Institute of Technology M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 Materials Science and Engineering. Formulation of oral dosage forms by three dimensional printing Formulation of oral dosage forms by 3D printing Thesis application/pdf false Publication unknown unknown <Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="831460de-6d8d-4afc-a5d3-fc6d63f3a938"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Formulation of oral dosage forms by three dimensional printing</Title> <Subtitle>Formulation of oral dosage forms by 3D printing</Subtitle> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>1998</PublicationDate> <Authors> <Author> <DisplayName>Palazzolo, Robert D. (Robert David), 1973-</DisplayName> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Massachusetts Institute of Technology</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>http://dspace.mit.edu/handle/1721.1/7582</License> <Keyword>Materials Science and Engineering.</Keyword> <Abstract>Pharmaceutical grade materials were used in the fabrication of fast-release and extended-release oral dosage forms. Tablets were processed by employing a method of solid freeform fabrication known as three dimensional printingTM (3DPTM). A microcrystalline cellulose powder was used in combination with pH-dependent and permeable polymeric binder solutions. Release studies in acidic media were performed using both dye and drug (antihistamine) as actives. Deposition was performed by micro pipette into concept devices. It was concluded that printing parameters could be used to control the microstructure and release behavior. The performance of a drop-on-demand inkjet printing system was evaluated to be highly accurate, and the system was used in the fabrication of model oral dosage forms. Tablets were constructed with a permeable polymer as binder. Mechanical tests showed that the tablets were comparable to industry references for both strength and friability. A USP dissolution method involving an acid and buffer stage was used for extended-release studies. Release by diffusion was found to depend on device porosity level and drug distribution as defined during fabrication.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication>